Saturated hydrocarbons
Medchemexpress LLC MD-224 10mM | 10MM 1ML
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept MD-224 consists of ligands for Cereblon and MDM2 MD-224 induces rapid degradation of MDM2 at concentrations 1 nM in human leukemia cells and achieves an IC50 value of 1 5 nM in inhibition of growth of RS4 11 cells MD-224 has the potential to be a new class of anticancer agent[1] MD-224 is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Cambridge Isotope Laboratories 2 2 4-TriBDE (BDE-17) (unlabeled) 50 ug/mL in nonane 1 2 mL
2 2 4-TriBDE (BDE-17) (unlabeled) 50 ug/mL in nonane 1 2 mL
Selleck Chemical LLC MD-224
MD-224 is a highly potent and effective degrader of the Human murine double minute 2 (MDM2) protein the main cellular inhibitor of the tumor suppressor p53 It strongly inhibits cell growth in leukemia cell lines with wild-type p53 and induces complete and lasting tumor regression in the RS4 11 xenograft tumor model
Medchemexpress LLC I-287 | 2014368-93-3 | 99.4% | 565.04 | 50 MG
I-287 is an orally active, selective PAR2 inhibitor that functions as a negative allosteric regulator of Gαq and Gα12/13 activity and their downstream effectors. It has been shown to reduce Complete Freund's adjuvant (CFA)-induced inflammation in mice and is suitable for inflammation/immunology research.
- Selectively targets Gαq and Gα12/13 signaling
- Inhibits PAR2-mediated activation of proteins without impacting βarrestin2 recruitment or receptor internalization
- Inhibits PAR2-mediated ERK1/2 activation in HEK293 cells
- Inhibits PAR2-induced secretion of IL-8 cytokine in HCT-116 and A549 cells
- Reduces inflammation in C57BL/6J mice
Cayman Chemical 12-hydroxy StearIc AcId 1g
A hydroxy fatty acid; a low molecular weight gelator that self-assembles to form organogels; administration of paclitaxel in 12-hydroxy stearic acid-containing gel nanocarriers enhances tumor growth suppression in an H22 murine hepatocellular carcinoma model
eMolecules 45223-18-5 | AstaTech | HEXADECANE 116-DIBROMO- | 0.25g | 248474199 | 29512 | 96 | MFCD00039195 | 384.24 | C16H32Br2
Ambeed | 2-Methoxy-4-(4455-tetramethyl-132-dioxaborolan-2-yl)benzaldehyde | 250mg | 572966221 | A515862 | 956431-01-9 | MFCD18732927 | 262.110 | C14H19BO4
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Cayman Chemical 12-oxo StearIc AcId 25mg
A metabolite of ricinoleic acid; has been found in cow and goat milk; dietary administration induces encephalomalacia in chicks fed a vitamin E-deficient diet
Cayman Chemical 12oxo Stearic Acid methyl est
An esterified form of 12-oxo stearic acid; has been found in esterified L. chinensis and L. decipiens pulp oils and serves as a measure of 12-oxo stearic acid content
eMolecules 76-09-5 | 2,3-DIMETHYLBUTANE-2,3-DIOL | AstaTech | MFCD00004462 | 118.176 | C6H14O2 | 95.000 | CC(C)(O)C(C)(C)O | 100g | 718071200
2,3-DIMETHYLBUTANE-2,3-DIOL | AstaTech | 76-09-5 | MFCD00004462 | 118.176 | C6H14O2 | 95.000 | CC(C)(O)C(C)(C)O | 100g | 718071200
Cayman Chemical 12oxo Stearic Acid methyl est
An esterified form of 12-oxo stearic acid; has been found in esterified L. chinensis and L. decipiens pulp oils and serves as a measure of 12-oxo stearic acid content
eMolecules 76-09-5 | 2,3-Dimethylbutane-2,3-diol | Synthonix - Stock | MFCD00004462 | 118.176 | C6H14O2 | 95.000 | CC(C)(O)C(C)(C)O | 25g | 452565329
2,3-Dimethylbutane-2,3-diol | Synthonix - Stock | 76-09-5 | MFCD00004462 | 118.176 | C6H14O2 | 95.000 | CC(C)(O)C(C)(C)O | 25g | 452565329
Cayman Chemical 2-chloro StearIc AcId 1mg
A bioactive fatty acid; accumulates in PMA-stimulated primary human monocytes and neutrophils as well as murine neutrophils; induces DNA release from primary human neutrophils